Approximately 1.2 million Americans suffer from wet age-related macular degeneration (wAMD).1
The current average age of AMD patients is 80 years old. The number of people with the disease is expected to double to 4.4 million by 2050 as the population ages.2

Wet AMD (wAMD) is an advanced form of AMD where blood vessels begin to invade the cellular space between layers of cells in the retina. These new blood vessels are often leaky, which results in fluid and blood in the retina and causes vision loss. While wAMD represents 10-15% of the number of cases of AMD overall, it is responsible for 90% of AMD-related severe vision loss.3-4 The disease is more common in Caucasians than in people of other ethnicities; age-related macular degeneration accounts for more than 54% of all vision loss in this population.5 Each year, approximately 150,000 Americans develop wAMD, with the number expected to grow due to the aging US population.6

Currently, wAMD is treated with frequent injections of anti-VEGF protein into the eye. This creates a burden for both patients and physicians, and limits access for those who are not able to comply with frequent office visits to receive injections.


  1. Arch Ophthalmol. 2004;122(4):564-572. doi:10.1001/archopht.122.4.564
  2. Wittenborn J. and Rein D. The Future of Vision: Forecasting the Prevalence and Costs of Vision Problems. June 2014.
  3. Rama D. Jager, M.D., William F. Mieler, M.D., and Joan W. Miller, M.D. Age-Related Macular Degeneration. N Engl J Med. 2008.
  4. AMD Alliance International. Basic Facts about AMD. Available online at http://www.amdalliance.org/information/basic-facts. Accessed on November 20, 2015.
  5. Congdon N, O’Colmain B, Klaver CC, Klein R, Muñoz B, Friedman DS, Kempen J, Taylor HR, Mitchell P, Eye Diseases Prevalence Research Group. Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol. 2004 Apr.
  6. Brown GC, Brown MM, Sharma S, et al. The Burden of Age-Related Macular Degeneration: A Value-Based Medicine Analysis. Transactions of the American Ophthalmological Society. 2005.

Resources for wAMD